ABSTRACT
Introduction: Following the trend of digital health applications, implemented especially during the COVID-19 pandemic, the ENDORSE project, is designed as an innovative integrated platform for supporting clinical decision making and telemedicine in children with Type 1 Diabetes Mellitus (T1DM), utilizing explainable artificial intelligence along with gamification and mobile technologies. Objective(s): Assessment of preliminary data from the prepilot phase of the ENDORSE feasibility trial. Method(s): ENDORSE platform utilizes various data sources such as glucose sensors (Flash Glucose Monitoring-FGM), smart insulin pen caps, activity trackers, mobile apps, Electronic Health Records and a newly developed serious game. A 13 T1DM children and adolescents (8 females, on multiple daily injections, mean diabetes duration 2, 57 years, mean HbA1c 7, 6%, mean Body Mass Index +1, 2 SDS, mean monitoring days: 151), followed in our Diabetes Center, were assessed regarding adherence to the study protocol. They all had internet access and only one has used a diabetes mobile application before. Result(s): As shown in Table 1, most of the patients used the Smart Insulin Pen Cap to document insulin and food data and many performed mobile FGM scanning, while the engagement to the ENDORSE serious game, aiming at training in self-disease management, along with the activity trackers is highly variable. Conclusion(s): ENDORSE platform along with changes in daily diabetes care practices like CGM usage, is expected to improve diabetes management through facilitating training, monitoring and feedback to the patients and their caregivers. In order to further improve its adherence and acceptance, factors such as the level of digital literacy and the need of a personalized experience to improve usability, should be also taken into consideration.